MKLP1 Rabbit Recombinant mAb Datasheet

生物描述

特异性	MKLP1 Rabbit Recombinant mAb detects endogenous level of total MKLP1.
背景	The MKLP1 (mitotic kinesin-like protein) is a component of centralspindlin complex that has been implicated in assembly of midzone/midbody during mitosis and is essential for cytokinesis. It is a downstream target of Cdc2/cyclin B1 and Cdk (cyclin-dependent kinase). phosphorylation of MKLP1 has been implicated to control the timing of midzone formation. MKLP1 is specifically localized to the dendrite of the developed neuron and transports microtubules from the cell body into the developing dendrite with their minus-ends leading, thereby establishing the pattern of non-uniform microtubule polarity in the dendrite. MKLP1 is necessary to maintain the minus-end-distal microtubules in the dendrite of developing and fully developed neuron.

特异性

MKLP1 Rabbit Recombinant mAb detects endogenous level of total MKLP1.

背景

The MKLP1 (mitotic kinesin-like protein) is a component of centralspindlin complex that has been implicated in assembly of midzone/midbody during mitosis and is essential for cytokinesis. It is a downstream target of Cdc2/cyclin B1 and Cdk (cyclin-dependent kinase). phosphorylation of MKLP1 has been implicated to control the timing of midzone formation. MKLP1 is specifically localized to the dendrite of the developed neuron and transports microtubules from the cell body into the developing dendrite with their minus-ends leading, thereby establishing the pattern of non-uniform microtubule polarity in the dendrite. MKLP1 is necessary to maintain the minus-end-distal microtubules in the dendrite of developing and fully developed neuron.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

98kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck