Datasheet

生物描述

特异性	MMP9 Rabbit Recombinant mAb detects endogenous levels of total MMP9.
背景	Matrix metalloproteinase (MMP)-mediated proteolysis plays a key role in modulation of cellular homeostasis: MMPs can initiate, amplify, or downregulate signaling cascades involved in growth and inflammation by activating cytokines and liberating sequestered growth factors, and can modify tissue architecture by degrading structural components of the extracellular matrix (ECM). MMP9 is a downstream effector and an upstream mediator of pathways involved in growth and inflammation. It may be involved in pathological processes that contribute to chronic inflammation, tumorigenesis, and metastasis. MMP-9 is secreted by a wide number of cell types, including neutrophils, macrophages, and fibroblasts. Neutrophils contain multiple proteases, such as serine proteases (elastase, cathepsin G, and proteinase 3), MMPs (MMP-8 and -9), and urokinase plasminogen activator (uPA). All proteases released from neutrophils promote MMP-9 activation. MMP-9 is upregulated during development and wound healing, as well as during pathologies that involve inflammatory processes, including arthritis, diabetes, and cancer. It also plays a significant role in neovascularization through the proteolytic degradation of the proteins in basal lamina of the blood vessels and a release of the biologically active form of vascular endothelial growth factor.

特异性

MMP9 Rabbit Recombinant mAb detects endogenous levels of total MMP9.

背景

Matrix metalloproteinase (MMP)-mediated proteolysis plays a key role in modulation of cellular homeostasis: MMPs can initiate, amplify, or downregulate signaling cascades involved in growth and inflammation by activating cytokines and liberating sequestered growth factors, and can modify tissue architecture by degrading structural components of the extracellular matrix (ECM). MMP9 is a downstream effector and an upstream mediator of pathways involved in growth and inflammation. It may be involved in pathological processes that contribute to chronic inflammation, tumorigenesis, and metastasis. MMP-9 is secreted by a wide number of cell types, including neutrophils, macrophages, and fibroblasts. Neutrophils contain multiple proteases, such as serine proteases (elastase, cathepsin G, and proteinase 3), MMPs (MMP-8 and -9), and urokinase plasminogen activator (uPA). All proteases released from neutrophils promote MMP-9 activation. MMP-9 is upregulated during development and wound healing, as well as during pathologies that involve inflammatory processes, including arthritis, diabetes, and cancer. It also plays a significant role in neovascularization through the proteolytic degradation of the proteins in basal lamina of the blood vessels and a release of the biologically active form of vascular endothelial growth factor.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Rat

MW (kDa)

78kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck