Motesanib (AMG-706)

目录号：S5793 批次号：S579301

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化学数据

化学结构式 别名 N/A 储存条件
(自收到货起)		 3年 -20°C 粉状
化学式

C22H23N5O
分子量 373.45 CAS号 453562-69-1
Solubility (25°C)* 体外 DMSO 18.2 mg/mL (48.73 mM)
Ethanol 8 mg/mL (21.42 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 Motesanib (AMG-706)是一种具有口服生物活性的受体酪氨酸激酶 (receptor tyrosine kinase)抑制剂，对VEGFR1, VEGFR2, VEGFR3, Kit, PDGFR和Ret的IC50值分别为2、3、6、8、84和59 nM。
靶点
VEGFR1 [1]
(Cell-free assay)		 VEGFR2 [1]
(Cell-free assay)		 VEGFR3 [1]
(Cell-free assay)		 c-Kit [1]
(Cell-free assay)		 c-Kit [1]
(Cell-free assay)		 View More
2 nM 3 nM 6 nM 8 nM 8 nM

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

Motesanib (AMG-706)在文献中得到引用

MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling [ Signal Transduct Target Ther, 2022, 7(1):147] PubMed: 35504869
Anosmin-1-Like Effect of UMODL1/Olfactorin on the Chemomigration of Mouse GnRH Neurons and Zebrafish Olfactory Axons Development [ Front Cell Dev Biol, 2022, 10:836179] PubMed: 35223856
Preclinical Evaluation of Ixabepilone in Combination with VEGF Receptor and PARP Inhibitors in Taxane-Sensitive and Taxane-Resistant MDA-MB-231 Breast Cancer Cells [ J Pharm Sci, 2022, 111(8):2180-2190] PubMed: 35700798
Organoid cultures derived from patients with papillary thyroid cancer [ J Clin Endocrinol Metab, 2021, dgab020] PubMed: 33524147
Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat [ Drug Metab Dispos, 2021, 49(1):53-61] PubMed: 33148688
Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets [ Cell Chem Biol, 2019, 10.1016/j.chembiol.2019.06.003] PubMed: 31257184
Multikinase inhibitor motesanib enhances the antitumor effect of cisplatin in cisplatin‑resistant human bladder cancer cells via apoptosis and the PI3K/Akt pathway. [ Oncol Rep, 2019, 41(4):2482-2490] PubMed: 30816494
[ Cancer Res, 2016, ] PubMed: 27488524
Dual inhibition of EGFR and MET induces synthetic lethality in triple-negative breast cancer cells through downregulation of ribosomal protein S6 [ Int J Oncol, 2015, 47(1):122-32] PubMed: 25955731
Antiangiogenic effects of topically administered multiple kinase inhibitor, motesanib (AMG 706), on experimental choroidal neovascularization in mice. [ J Ocul Pharmacol Ther, 2015, 31(1):25-31] PubMed: 25255037

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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