生物描述

特异性

MSH2 Rabbit Recombinant mAb detects endogenous levels of total MSH2.

背景

DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. In eukaryotes, Msh2 (MutS homologue 2) is a major player in MMR, functioning as a heterodimer in association with Msh3 or Msh6. Msh2 is also a component of the BRCA-1-associated genome surveillance complex, a multiprotein complex involved in the recognition and response to abnormal DNA structures. MSH2 may colocalize with Msh6, p53, BLM, and Rad51 at sites of DSBs at stalled replication forks in human cells and help regulate the processing of recombination intermediates and the repair of DSBs. MSH2 is a tumor suppressor. Deficiency in Msh2 results in increased mutation rate, global instability of microsatellite sequences, and increased rates of recombination between diverged sequences.

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human
MW (kDa)	105kDa
抗体类型
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Guo-Min Li. Cell Research. 2008, 18: 85-98. [2] Jason A. Smith, et al. Genetics. 2005, 170(1): 355-363.

Application Data

WB

IF