MSH6 Rabbit Recombinant mAb

生物描述

特异性

MSH6 Rabbit Recombinant mAb detects endogenous level of MSH6.

背景

MutS homologue 6 (MSH6) is an ATPase that is part of the MSH2-MSH6 complex and has been shown in Homo sapiens (Human) to bind to mismatched DNA directly in the ADP-bound state. The MSH6 has members from yeasts, plants, fish, and mammals. After DNA replication, a low level of replication errors exist, including base-pair mismatches. In bacteria, it was shown that MutS acts with MutL, MutH, and UvrD to correct these errors. In Human, it was shown that MSH2 and MSH6 are involved in the BASC complex (BRCA1-associated genome surveillance complex) with many other proteins including MLH1, RAD50, MRE11, NBS1, RFC1, RFC2, RFC4, BRCA1, ATM, and BLM.

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	163kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Gradia S, et al. Cell. 1997, 91(7):995-1005. [2] Wang Y, et al. Genes Dev. 2000, 14(8):927-39.

Application Data

WB

IF