MTA2 Rabbit Recombinant mAb Datasheet

生物描述

特异性	MTA2 Rabbit Recombinant mAb detects endogenous level of total MTA2.
背景	The metastasis associated (MTA) family of proteins have been demonstrated to be associated with breast tumor cell progression and ERα activity. MTA2 is the second member of the MTA family of genes. MTA2 is contained in nucleosome remodeling and histone deacetylation (NuRD) complexes that are involved in both nucleosome remodeling and which possess histone deacetylase activity. MTA2 expression enhances p53 deacetylation through targeting of p53 to HDACs, thereby strongly repressing p53-dependent transcriptional activation. MTA2 binds to ERα and inhibits the transcriptional activity of wild-type ERα, functioning as a receptor repressor.

特异性

MTA2 Rabbit Recombinant mAb detects endogenous level of total MTA2.

背景

The metastasis associated (MTA) family of proteins have been demonstrated to be associated with breast tumor cell progression and ERα activity. MTA2 is the second member of the MTA family of genes. MTA2 is contained in nucleosome remodeling and histone deacetylation (NuRD) complexes that are involved in both nucleosome remodeling and which possess histone deacetylase activity. MTA2 expression enhances p53 deacetylation through targeting of p53 to HDACs, thereby strongly repressing p53-dependent transcriptional activation. MTA2 binds to ERα and inhibits the transcriptional activity of wild-type ERα, functioning as a receptor repressor.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human

MW (kDa)

75kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Yukun Cui, et al. Mol Endocrinol. 2006, 20(9): 2020-2035.

Application Data

WB

Validated by Selleck