Datasheet

生物描述

特异性	MVP Rabbit Recombinant mAb detects endogenous levels of total MVP
背景	Major vault protein (MVP), also called lung resistance-related protein (LRP), is a ribonucleoprotein comprising a major part (>70%) of the vault particle. MVP is increasingly expressed in certain carcinoma and leukemia cells that are refractory to drug treatment (chemotherapy). It was suggested that the MVP might alleviate the effect of chemotherapeutics on target cells. The structure and subcellular localization of the vault particles are consistent with possible function of MVP in the intracellular transport of drugs. MVP also interacts with the activated form of extracellular-regulated protein tyrosine kinase (ERK signal-regulated), suggesting a role of MVP as a scaffold protein in tyrosine-phosphorylation-dependent signaling pathways.

特异性

MVP Rabbit Recombinant mAb detects endogenous levels of total MVP

背景

Major vault protein (MVP), also called lung resistance-related protein (LRP), is a ribonucleoprotein comprising a major part (>70%) of the vault particle. MVP is increasingly expressed in certain carcinoma and leukemia cells that are refractory to drug treatment (chemotherapy). It was suggested that the MVP might alleviate the effect of chemotherapeutics on target cells. The structure and subcellular localization of the vault particles are consistent with possible function of MVP in the intracellular transport of drugs. MVP also interacts with the activated form of extracellular-regulated protein tyrosine kinase (ERK signal-regulated), suggesting a role of MVP as a scaffold protein in tyrosine-phosphorylation-dependent signaling pathways.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

99kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Sutovsky P, et al. Reproduction. 2005;129(3):269-82.

Application Data

WB

Validated by Selleck