Nilotinib hydrochloride

目录号：S5205 批次号：S520503

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化学数据

化学结构式 别名 AMN-107 HCl 储存条件
(自收到货起)		 3年 -20°C 粉状
化学式

C28H22F3N7O.HCl
分子量 565.98 CAS号 923288-95-3
Solubility (25°C)* 体外 DMSO 100 mg/mL (176.68 mM)
Ethanol 2 mg/mL (3.53 mM)
Water Insoluble
体内（现配现用）
澄清溶液
2% DMSO 40% PEG 300 5%Tween80 53%ddH2O
2mg/ml (3.53mM) 以 1 mL 工作液为例,取20 μL 100mg/ml的澄清DMSO储备液加到400 μL PEG300中,混合均匀使其澄清;向上述体系中加入50 μL Tween80,混合均匀使其澄清;然后继续加入530 μL ddH2O定容至1 mL。工作液请现配现用!
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述 Nilotinib hydrochloride (AMN-107) is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
靶点
Bcr-Abl [1]
(Murine myeloid progenitor cells)
<30 nM

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

Nilotinib hydrochloride在文献中得到引用

Comprehensive multi-omics analysis reveals WEE1 as a synergistic lethal target with hyperthermia through CDK1 super-activation [ Nat Commun, 2024, 15(1):2089] PubMed: 38453961
Preclinical Evaluation of Ixabepilone in Combination with VEGF Receptor and PARP Inhibitors in Taxane-Sensitive and Taxane-Resistant MDA-MB-231 Breast Cancer Cells [ J Pharm Sci, 2022, 111(8):2180-2190] PubMed: 35700798
Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix-mediated tumor cell adaptation and tolerance to BRAF-targeted therapy in melanoma [ EMBO Mol Med, 2021, e11814] PubMed: 34957688
Antimetabolic cooperativity with the clinically approved l-asparaginase and tyrosine kinase inhibitors to eradicate CML stem cells [ Mol Metab, 2021, 55:101410] PubMed: 34863941
CXCR2, a novel target to overcome tyrosine kinase inhibitor resistance in chronic myelogenous leukemia cells [ Biochem Pharmacol, 2021, 190:114658] PubMed: 34146540
Imatinib can act as an Allosteric Activator of Abl Kinase [ J Mol Biol, 2021, 434(2):167349] PubMed: 34774565
Statins Enhance the Molecular Response in Chronic Myeloid Leukemia when Combined with Tyrosine Kinase Inhibitors [ Cancers (Basel), 2021, 13(21)5543] PubMed: 34771705
Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat [ Drug Metab Dispos, 2021, 49(1):53-61] PubMed: 33148688
ABL1 and Cofilin1 promote T-cell acute lymphoblastic leukemia cell migration [ Acta Biochim Biophys Sin (Shanghai), 2021, gmab117] PubMed: 34508625
Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1T315I and BCR-ABL1T315I-E255K [ Ann Hematol, 2021, 10.1007/s00277-020-04357-z] PubMed: 34110462

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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