Nintedanib Ethanesulfonate Salt

目录号：S5234 批次号：S523401

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化学数据

化学结构式 别名 Intedanib, BIBF 1120 储存条件
(自收到货起)		 3年 -20°C 粉状
化学式

C31H33N5O4.C2H6O3S
分子量 649.76 CAS号 656247-18-6
Solubility (25°C)* 体外 DMSO 100 mg/mL (153.9 mM)
Water 12.5 mg/mL (19.23 mM)
Ethanol 5 mg/mL (7.69 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 Nintedanib (Intedanib, BIBF 1120) is a small molecule tyrosine-kinase inhibitor with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β, respectively.
靶点
VEGFR2 [1]
(Cell-free assay)		 VEGFR3 [1]
(Cell-free assay)		 VEGFR1 [1]
(Cell-free assay)		 FGFR2 [1]
(Cell-free assay)		 PDGFRα [1]
(Cell-free assay)		 View More
13 nM 13 nM 34 nM 37 nM 59 nM

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

Nintedanib Ethanesulfonate Salt在文献中得到引用

Antineoplastic efficacy profiles of avapritinib and nintedanib in KIT D816V+ systemic mastocytosis: a preclinical study [ Am J Cancer Res, 2023, 13(2):355-378] PubMed: 36895976
Nintedanib enhances the efficacy of PD-L1 blockade by upregulating MHC-I and PD-L1 expression in tumor cells [ Theranostics, 2022, 12(2):747-766] PubMed: 34976211
Blockade of the pro-fibrotic reaction mediated by the miR-143/-145 cluster enhances the responses to targeted therapy in melanoma [ EMBO Mol Med, 2022, 14(3):e15295] PubMed: 35156321
FOXA1 prevents nutrients deprivation induced autophagic cell death through inducing loss of imprinting of IGF2 in lung adenocarcinoma [ Cell Death Dis, 2022, 13(8):711] PubMed: 35974000
Impairment of the Retinal Endothelial Cell Barrier Induced by Long-Term Treatment with VEGF-A165 No Longer Depends on the Growth Factor's Presence [ Biomolecules, 2022, 12(5)734] PubMed: 35625661
Beovu, but not Lucentis impairs the function of the barrier formed by retinal endothelial cells in vitro [ Sci Rep, 2022, 12(1):12493] PubMed: 35864147
Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients [ Anticancer Drugs, 2022, 10.1097/CAD.0000000000001344] PubMed: 36066384
Contracting scars from fibrin drops [ Integr Biol (Camb), 2022, 14(1):1-12] PubMed: 35184163
Targeting fibroblast growth factor receptors to combat aggressive ependymoma [ Acta Neuropathol, 2021, 10.1007/s00401-021-02327-x] PubMed: 34046693
The tyrosine-kinase inhibitor Nintedanib ameliorates autosomal-dominant polycystic kidney disease [ Cell Death Dis, 2021, 12(10):947] PubMed: 34650051

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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