NUMB Rabbit Recombinant mAb Datasheet

生物描述

特异性	NUMB Rabbit Recombinant mAb detects endogenous level of total NUMB.
背景	NUMB (protein numb homologue) is the human homologue of the protein numb that was initially discovered in Drosophila melanogaster as an adaptor protein responsible for recruiting proteins into different signalling pathways. NUMB is an evolutionarily conserved protein well-known for its multifaceted role in neurogenesis and cellular homeostasis within the peripheral and central nervous systems. NUMB is a complex protein with multiple cellular functions. It has a prominent role in the control of cell fate within the Hedgehog and p53 signalling pathways. NUMB negatively regulates the NOTCH signalling pathway. Targeting NUMB has potential to control prostate tumorigenesis.

特异性

NUMB Rabbit Recombinant mAb detects endogenous level of total NUMB.

背景

NUMB (protein numb homologue) is the human homologue of the protein numb that was initially discovered in Drosophila melanogaster as an adaptor protein responsible for recruiting proteins into different signalling pathways. NUMB is an evolutionarily conserved protein well-known for its multifaceted role in neurogenesis and cellular homeostasis within the peripheral and central nervous systems. NUMB is a complex protein with multiple cellular functions. It has a prominent role in the control of cell fate within the Hedgehog and p53 signalling pathways. NUMB negatively regulates the NOTCH signalling pathway. Targeting NUMB has potential to control prostate tumorigenesis.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

71kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Flores AN, et al. Nat Rev Urol. 2014, 11(9):499-507.

Application Data

WB

Validated by Selleck