p57 Kip2 Rabbit Recombinant mAb Datasheet

生物描述

特异性	p57 Kip2 Rabbit Recombinant mAb detects endogenous level of total p57 Kip2.
背景	p57Kip2 is a cyclin-dependent kinase inhibitor belonging to the Cip/Kip family, which also includes p21Cip1 and p27Kip1. p57Kip2 controls organogenesis, embryogenesis, and cell differentiation. Distinct from its activity as a CDK inhibitor, p57Kip2 is a master regulator of erythrocytic differentiation. Like the other Cip/Kip proteins, p57Kip2 can repress transcription indirectly by inhibiting cyclin-CDK complexes, in turn preventing the phosphorylation of Rb-family proteins (p107, p110, and p130).

特异性

p57 Kip2 Rabbit Recombinant mAb detects endogenous level of total p57 Kip2.

背景

p57Kip2 is a cyclin-dependent kinase inhibitor belonging to the Cip/Kip family, which also includes p21Cip1 and p27Kip1. p57Kip2 controls organogenesis, embryogenesis, and cell differentiation. Distinct from its activity as a CDK inhibitor, p57Kip2 is a master regulator of erythrocytic differentiation. Like the other Cip/Kip proteins, p57Kip2 can repress transcription indirectly by inhibiting cyclin-CDK complexes, in turn preventing the phosphorylation of Rb-family proteins (p107, p110, and p130).

使用信息

抗体应用

WB, IHC, IF,ELISA,ELISA

稀释比例

WB	IHC	IF
1:1000	1:50	1:50

反应性

Human Mouse Rat

MW (kDa)

57kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Borriello A, et al. Mol Cancer Res. 2011, 9(10):1269-84.

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck

IF

Validated by Selleck