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别名 | PD 0332991 | 储存条件 (自收到货起) |
3年 -20°C 粉状 | |
化学式 | C24H29N7O2 |
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分子量 | 447.53 | CAS号 | 571190-30-2 | |
Solubility (25°C)* | 体外 | 5% TFA | 5 mg/mL (11.17 mM) | |
DMSO | Insoluble | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | Palbociclib (PD 0332991) 是一种高度特异性的 cyclin-dependent kinase 4 (Cdk4) 和 Cdk6 的抑制剂,IC50值分别为11 nM和16 nM。此产品溶解度不佳,动物实验可用,细胞实验请谨慎选择! | ||||
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Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment [ Cancer Cell, 2024, S1535-6108(24)00037-0] | PubMed: 38402610 |
Transcription-coupled DNA-protein crosslink repair by CSB and CRL4CSA-mediated degradation [ Nat Cell Biol, 2024, 10.1038/s41556-024-01394-y] | PubMed: 38600236 |
A renal clearable fluorogenic probe for in vivo β-galactosidase activity detection during aging and senolysis [ Nat Commun, 2024, 15(1):775] | PubMed: 38278798 |
Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma [ Clin Cancer Res, 2024, 30(4):703-718] | PubMed: 37695642 |
Intracellular calcium links milk stasis to lysosome-dependent cell death during early mammary gland involution [ Cell Mol Life Sci, 2024, 81(1):29] | PubMed: 38212474 |
DUB3 is a MAGEA3 deubiquitinase and a potential therapeutic target in hepatocellular carcinoma [ iScience, 2024, 27(3):109181] | PubMed: 38414853 |
Testing Adaptive Therapy Protocols Using Gemcitabine and Capecitabine in a Preclinical Model of Endocrine-Resistant Breast Cancer [ Cancers (Basel), 2024, 16(2)257] | PubMed: 38254748 |
IRF3 activates RB to authorize cGAS-STING-induced senescence and mitigate liver fibrosis [ Sci Adv, 2024, 10(9):eadj2102] | PubMed: 38416816 |
The Combination of Afatinib With Dasatinib or Miransertib Results in Synergistic Growth Inhibition of Stomach Cancer Cells [ World J Oncol, 2024, 15(2):192-208] | PubMed: 38545471 |
Acute multi-level response to defective de novo chromatin assembly in S-phase [ bioRxiv, 2024, 2024.03.22.586291] | PubMed: 38585916 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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1. 请在返还样品之前事先与我们取得联系,以确保产品是直接向我们或者当地代理商购买的;
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