PAX7 Rabbit Recombinant mAb Datasheet

生物描述

特异性	PAX7 Rabbit Recombinant mAb detects endogenous level of total PAX7.
背景	Pax genes play key roles during development. Members of this family of paired box/homeodomain transcription factors regulate the contribution of progenitor cells to different tissue types. Pax3 and its paralogue Pax7 have been implicated in the specification of cells that will enter the myogenic program. Pax7 is present in satellite cells, and in its absence muscle regeneration is severely affected. Pax7 is present in quiescent satellite cells and during their activation, but is down-regulated when they differentiate. A proportion of activated satellite cells remain undifferentiated, retain Pax7 expression, and are thought to reconstitute the satellite cell pool. Thus, Pax7 is a satellite cell marker.

特异性

PAX7 Rabbit Recombinant mAb detects endogenous level of total PAX7.

背景

Pax genes play key roles during development. Members of this family of paired box/homeodomain transcription factors regulate the contribution of progenitor cells to different tissue types. Pax3 and its paralogue Pax7 have been implicated in the specification of cells that will enter the myogenic program. Pax7 is present in satellite cells, and in its absence muscle regeneration is severely affected. Pax7 is present in quiescent satellite cells and during their activation, but is down-regulated when they differentiate. A proportion of activated satellite cells remain undifferentiated, retain Pax7 expression, and are thought to reconstitute the satellite cell pool. Thus, Pax7 is a satellite cell marker.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

57kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck