PCNA Rabbit Recombinant mAb Datasheet

生物描述

特异性	PCNA Rabbit Recombinant mAb detects endogenous level of total PCNA.
背景	Proliferating cell nuclear antigen (PCNA) is an evolutionarily well-conserved protein found in all eukaryotic species as well as in Archaea and belongs to DNA sliding clamp family. PCNA was first shown to act as a processivity factor of DNA polymerase δ, which is required for DNA synthesis during replication. However, besides DNA replication, PCNA functions are associated with other vital cellular processes such as chromatin remodelling, DNA repair, sister-chromatid cohesion and cell cycle control. The expression levels of PCNA are associated with proliferation or neoplastic transformation.

特异性

PCNA Rabbit Recombinant mAb detects endogenous level of total PCNA.

背景

Proliferating cell nuclear antigen (PCNA) is an evolutionarily well-conserved protein found in all eukaryotic species as well as in Archaea and belongs to DNA sliding clamp family. PCNA was first shown to act as a processivity factor of DNA polymerase δ, which is required for DNA synthesis during replication. However, besides DNA replication, PCNA functions are associated with other vital cellular processes such as chromatin remodelling, DNA repair, sister-chromatid cohesion and cell cycle control. The expression levels of PCNA are associated with proliferation or neoplastic transformation.

使用信息

抗体应用

WB, IHC,ELISA,ELISA

稀释比例

WB	IHC
1:2000	1:50

反应性

Human Mouse Rat

MW (kDa)

29kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Wojciech Strzalka, et al. Ann Bot. 2011, 107(7): 1127-1140.

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck