PD-1/PD-L1 Inhibitor 3

目录号：S8158 批次号：S815801

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₈₉H₁₂₆N₂₄O₁₈S
	分子量	1852.17	CAS号	1629654-95-0
Solubility (25°C)*	体外	DMSO	100 mg/mL (53.99 mM)
		Water	100 mg/mL (53.99 mM)
		Ethanol	100 mg/mL (53.99 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

PD-1/PD-L1 Inhibitor 3（程序性细胞死亡蛋白-1/程序性细胞死亡配体1-抑制剂3）是一种PD-1/PD-L1相互作用的环肽类抑制剂，IC50为5.6 nM。

靶点

PD-1/PD-L1 interaction ^[1]
(Cell-free assay)

5.6 nM

体外研究

PD-1/PD-L1 Inhibitor 3能够抑制PD-L1与PD-1的相互作用以及其与CD80的相互作用。PD-1/PD-L1 Inhibitor 3对PD-L1d具有高效结合力，能促进增强的T细胞功能活性^[1]。

参考文献

[1] MILLER Michael Matthew, et al. Patent, Pub. No.:WO/2014/151634.

PD-1/PD-L1 Inhibitor 3在文献中得到引用

Development and In Vivo Evaluation of Small-Molecule Ligands for Positron Emission Tomography of Immune Checkpoint Modulation Targeting Programmed Cell Death 1 Ligand 1 [ J Med Chem, 2024, 67(5):4036-4062]	PubMed: 38442487
On the Road towards Small-Molecule Programmed Cell Death 1 Ligand 1 Positron Emission Tomography Tracers: A Ligand-Based Drug Design Approach [ Pharmaceuticals (Basel), 2023, 16(7)1051]	PubMed: 37513962
Myricetin inhibits interferon-γ-induced PD-L1 and IDO1 expression in lung cancer cells [ Biochem Pharmacol, 2022, 197:114940]	PubMed: 35120895
Myricetin inhibits interferon-γ-induced PD-L1 and IDO1 expression in lung cancer cells [ Biochem Pharmacol, 2022, 197:114940]	PubMed: 35120895
FAK Regulates VEGFR2 Expression and Promotes Angiogenesis in Triple-Negative Breast Cancer [ ChemMedChem, 2022, e202200091]	PubMed: 35388635
A mating mechanism to generate diversity for the Darwinian selection of DNA-encoded synthetic molecules [ Nat Chem, 2021, 10.1038/s41557-021-00829-5]	PubMed: 34873299
MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β [ Exp Mol Med, 2021, 53(9):1366-1378]	PubMed: 34548615
The Stone Guest: How Does pH Affect Binding Properties of PD-1/PD-L1 Inhibitors [ ChemMedChem, 2021, 16(3):568-577]	PubMed: 33085193
Blockade of Kv1.3 potassium channel inhibits CD8+ T cell-mediated neuroinflammation via PD-1/Blimp-1 signaling [ FASEB J, 2020, 10.1096/fj.202000861RR]	PubMed: 32981181
eEF2K enhances expression of PD-L1 by promoting the translation of its mRNA [ Biochem J, 2020, BCJ20200697]	PubMed: 33094805

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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