PDK1 Rabbit Recombinant mAb Datasheet

生物描述

特异性	PDK1 Rabbit Recombinant mAb detects endogenous level of PDK1.
背景	3-phosphoinositide dependent protein kinase-1 (PDK1 or PDPK1) is implicated in signaling pathways frequently altered in cancer, such as PI3K/Akt, Ras/MAPK and Myc. It is traditionally known to phosphorylate PKB/Akt and is responsible for the phosphorylation of many other AGC kinases including p70 ribosomal protein S6 kinase (p70S6K), serum/glucocorticoid regulated kinase (SGK), p90 ribosomal protein S6 kinase (p90RSK) and the members of protein kinase C (PKC) family. The aberrant activation of these and other PDK1 downstream effectors has been reported to be involved in pathological phenotypes such as uncontrolled cell replication, apoptosis escape, invasion and dissemination, metastasis, metabolic reprogramming and abnormal angiogenesis.

特异性

PDK1 Rabbit Recombinant mAb detects endogenous level of PDK1.

背景

3-phosphoinositide dependent protein kinase-1 (PDK1 or PDPK1) is implicated in signaling pathways frequently altered in cancer, such as PI3K/Akt, Ras/MAPK and Myc. It is traditionally known to phosphorylate PKB/Akt and is responsible for the phosphorylation of many other AGC kinases including p70 ribosomal protein S6 kinase (p70S6K), serum/glucocorticoid regulated kinase (SGK), p90 ribosomal protein S6 kinase (p90RSK) and the members of protein kinase C (PKC) family. The aberrant activation of these and other PDK1 downstream effectors has been reported to be involved in pathological phenotypes such as uncontrolled cell replication, apoptosis escape, invasion and dissemination, metastasis, metabolic reprogramming and abnormal angiogenesis.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

49kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Gagliardi PA, et al. Semin Cancer Biol. 2017.

Application Data

WB

Validated by Selleck