PEBP1 Rabbit Recombinant mAb Datasheet

生物描述

特异性	PEBP1 Rabbit Recombinant mAb detects endogenous level of total PEBP1.
背景	PEBP1 (phosphatidylethanolamine binding protein 1) is originally identified as a PE-binding protein and also a cellular inhibitor of MAPK/ERK signaling. It inhibits the RAF-MEK-MAPK/ERK pathway by directly blocking RAF1 activation. PEBP1 also functions as a cellular controller for G protein-coupled receptor signaling, as well as NFKB activation by modulating the IKK complex, MAP3K14/NIK (mitogen-activated protein kinase kinase kinase 14), and MAP3K7/TAK1 (mitogen-activated protein kinase kinase kinase 7). Moreover, PEBP1 is a precursor for the hippocampal neurostimulating peptide (HCNP), which is involved in neuronal differentiation. PEBP1 specially binds to LC3 and inhibit autophagy induced by nutrient deprivation.

特异性

PEBP1 Rabbit Recombinant mAb detects endogenous level of total PEBP1.

背景

PEBP1 (phosphatidylethanolamine binding protein 1) is originally identified as a PE-binding protein and also a cellular inhibitor of MAPK/ERK signaling. It inhibits the RAF-MEK-MAPK/ERK pathway by directly blocking RAF1 activation. PEBP1 also functions as a cellular controller for G protein-coupled receptor signaling, as well as NFKB activation by modulating the IKK complex, MAP3K14/NIK (mitogen-activated protein kinase kinase kinase 14), and MAP3K7/TAK1 (mitogen-activated protein kinase kinase kinase 7). Moreover, PEBP1 is a precursor for the hippocampal neurostimulating peptide (HCNP), which is involved in neuronal differentiation. PEBP1 specially binds to LC3 and inhibit autophagy induced by nutrient deprivation.

使用信息

抗体应用

WB, IHC,ELISA,ELISA

稀释比例

WB	IHC
1:1000	1:50

反应性

Human Mouse Rat

MW (kDa)

21kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Noh HS, et al. Autophagy. 2016, 12(11):2183-2196.

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck