Phospho-PAK1/2/3(S144/S141/S139) Rabbit Recombinant mAb

生物描述

特异性

Phospho-PAK1/2/3(S144/S141/S139) Rabbit Recombinant mAb detects endogenous level of total Phospho-PAK1/2/3(S144/S141/S139).

背景

The p21-activated kinases (PAKs) are ubiquitous serine/threonine protein kinases that interact with the activated GTP-bound forms of Cdc42 or Rac1. PAKs are regulated by a variety of extracellular signals that impinge on these small GTPas. This family comprised of six isoforms (PAK1-6), and they play important roles in cytoskeletal dynamics, cell survival and proliferation. They also act as key signal transducers in several cancer signaling pathways, including Ras, Raf, NF-kB, Akt, Bad and p53. PAK1, PAK2 and PAK3 are Group I PAKs. Group I PAKs are downstream targets of Merlin. Merlin associates with inactive PAK and prevents its activation, perhaps by competing with Rac. The site S144 of PAK1, S141 of PAK2 and S139 of PAK3 are auto-phosphorylation sites.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	65kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Ye DZ, et al. Cell Logist. 2012, 2(2):105-116.

Application Data

WB

IHC