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目录号:A5943
特异性 | Phospho-PP2A (Y307) Rabbit Recombinant mAb detects endogenous levels of phosphorylated PP2A (Y307). |
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背景 | Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell cycle, regulating almost all major pathways and cell cycle checkpoints. PP2A is involved in such diverse processes by the formation of structurally distinct families of holoenzymes, which are regulated spatially and temporally by specific regulators. In vitro phosphorylation of PP2A at Y307 by protein tyrosine kinases led to its inactivation with relevance in chronic and acute leukaemias or Alzheimer's disease. Aβ accumulation or the oestrogen deficiency may mediate the up-regulation of PP2A phosphorylation (Y307), which in turn contributes to the reduced PP2A activity in the AD brain. |
抗体应用 | WB,ELISA,ELISA | ||
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稀释比例 |
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反应性 | Human Mouse Rat | ||
MW (kDa) | 35kDa | ||
抗体类型 | |||
储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
储存条件 (自收到货起) |
Store at –20°C. |
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WB
Validated by Selleck