Datasheet

生物描述

特异性	Phospho-Rb (S807) Rabbit Recombinant mAb detects endogenous levels of total Phospho-Rb (S807).
背景	The Retinoblastoma (Rb) tumor suppressor protein is regulated by phosphorylation and plays a role in several important cellular processes such as proliferation, differentiation, senescence and apoptosis. The global conformational changes that occur in Rb upon phosphorylation are site-specific and remarkably diverse. Rb phosphorylated on at least 4 C-terminal phosphorylation sites (S608, S795, S807/S811, and T821) is present at the mitochondria under non-stressed cellular conditions. Phosphorylation of S807 of Rb is important for association of Rb with Bax and acts as a priming mechanism to promote phosphorylation of other sites of Rb.

特异性

Phospho-Rb (S807) Rabbit Recombinant mAb detects endogenous levels of total Phospho-Rb (S807).

背景

The Retinoblastoma (Rb) tumor suppressor protein is regulated by phosphorylation and plays a role in several important cellular processes such as proliferation, differentiation, senescence and apoptosis. The global conformational changes that occur in Rb upon phosphorylation are site-specific and remarkably diverse. Rb phosphorylated on at least 4 C-terminal phosphorylation sites (S608, S795, S807/S811, and T821) is present at the mitochondria under non-stressed cellular conditions. Phosphorylation of S807 of Rb is important for association of Rb with Bax and acts as a priming mechanism to promote phosphorylation of other sites of Rb.

使用信息

抗体应用

wb,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

106kDa

抗体类型

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck