Phospho-SHP2 (Y542) Rabbit Recombinant mAb Datasheet

生物描述

特异性	Phospho-SHP2 (Y542) Rabbit Recombinant mAb detects endogenous level of total Phospho-SHP2 (Y542).
背景	SHP-2, a cytoplasmic SH2 domain containing protein tyrosine phosphatase, is ubiquitously expressed in various tissues and cell types. SHP-2 and has been implicated in diverse signaling pathways including those initiated by growth factors such as PDGF, EGF, and IGF-1, cytokines such as IL-3, GM-CSF, and EPO, as well as insulin and interferon. SHP-2 has compound signaling functions. It appears to be involved in a variety of signal transduction processes, such as the Ras-Raf-MAP kinase, Jak-Stat, and PI3 kinase pathways. Within a single signaling pathway, SHP-2 may act at multiple sites to participate in the signal relay.

特异性

Phospho-SHP2 (Y542) Rabbit Recombinant mAb detects endogenous level of total Phospho-SHP2 (Y542).

背景

SHP-2, a cytoplasmic SH2 domain containing protein tyrosine phosphatase, is ubiquitously expressed in various tissues and cell types. SHP-2 and has been implicated in diverse signaling pathways including those initiated by growth factors such as PDGF, EGF, and IGF-1, cytokines such as IL-3, GM-CSF, and EPO, as well as insulin and interferon. SHP-2 has compound signaling functions. It appears to be involved in a variety of signal transduction processes, such as the Ras-Raf-MAP kinase, Jak-Stat, and PI3 kinase pathways. Within a single signaling pathway, SHP-2 may act at multiple sites to participate in the signal relay.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse

MW (kDa)

68kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Cheng Kui Qu. Cell Research. 2000, 10: 279-288.

Application Data

WB

Validated by Selleck