Phospho-Smad2 (S250) Rabbit Recombinant mAb Datasheet

生物描述

特异性	Phospho-Smad2 (S250) Rabbit Recombinant mAb detects endogenous level of total phospho-Smad2 (S250).
背景	The Transforming Growth Factor-Beta (TGF-β) family is involved in regulating a variety of cellular processes such as apoptosis, differentiation, and proliferation. TGF-β binding to a Serine/Threonine kinase receptor complex causes the recruitment and subsequent activation of transcription factors known as smad2 and smad3. Within the linker region domains of smad2 and smad3 are several potential Erk phosphorylation sites (Ser 245, 250, and 255). These clustered serine residues are preferred phosphorylation sites for ERK, JNK and p38 in response to receptor tyrosine kinases and proinflammatory cytokines.

特异性

Phospho-Smad2 (S250) Rabbit Recombinant mAb detects endogenous level of total phospho-Smad2 (S250).

背景

The Transforming Growth Factor-Beta (TGF-β) family is involved in regulating a variety of cellular processes such as apoptosis, differentiation, and proliferation. TGF-β binding to a Serine/Threonine kinase receptor complex causes the recruitment and subsequent activation of transcription factors known as smad2 and smad3. Within the linker region domains of smad2 and smad3 are several potential Erk phosphorylation sites (Ser 245, 250, and 255). These clustered serine residues are preferred phosphorylation sites for ERK, JNK and p38 in response to receptor tyrosine kinases and proinflammatory cytokines.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

58kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

Application Data

WB

Validated by Selleck