PI3 Kinase p110 beta Rabbit Recombinant mAb Datasheet

生物描述

特异性	PI3 Kinase p110 beta Rabbit Recombinant mAb detects endogenous level of total PI3 Kinase p110 beta.
背景	PI3-K is a heterodimer consisting of a regulatory and a catalytic subunit. The catalytic subunits p110α, β, and δ have been shown to be associated with p85α, p85β and p55γ adapter proteins which mediate activation by protein tyrosine kinase receptors. The p110γ isoform, in contrast, binds to a p101 adapter protein and is associated with and activated by βγ subunits of G proteins. The p110 α and p110β isoforms are both widely expressed whereas the p110δ subunit is predominantly expressed in haematopoietic cells. The p85 subunit contains a wide range of domains involved in protein-protein interactions.

特异性

PI3 Kinase p110 beta Rabbit Recombinant mAb detects endogenous level of total PI3 Kinase p110 beta.

背景

PI3-K is a heterodimer consisting of a regulatory and a catalytic subunit. The catalytic subunits p110α, β, and δ have been shown to be associated with p85α, p85β and p55γ adapter proteins which mediate activation by protein tyrosine kinase receptors. The p110γ isoform, in contrast, binds to a p101 adapter protein and is associated with and activated by βγ subunits of G proteins. The p110 α and p110β isoforms are both widely expressed whereas the p110δ subunit is predominantly expressed in haematopoietic cells. The p85 subunit contains a wide range of domains involved in protein-protein interactions.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

110kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Hooshmand-Rad R, et al. J Cell Sci. 2000, 113 Pt 2:207-14.

Application Data

WB

Validated by Selleck