PKC delta Rabbit Recombinant mAb Datasheet

生物描述

特异性	PKC delta Rabbit Recombinant mAb detects endogenous level of total PKC delta.
背景	PKC delta is expressed ubiquitously among cells and tissues. It is activated by diacylglycerol produced by receptor-mediated hydrolysis of membrane inositol phospholipids as well as by tumor-promoting phorbol ester through the binding of these compounds to the C1 region in its regulatory domain. It is also cleaved by caspase to generate a catalytically active fragment, and it is converted to an active form without proteolysis through the tyrosine phosphorylation reaction. PKC delta activated in distinct ways plays critical roles in cellular functions such as the control of growth, differentiation, and apoptosis.

特异性

PKC delta Rabbit Recombinant mAb detects endogenous level of total PKC delta.

背景

PKC delta is expressed ubiquitously among cells and tissues. It is activated by diacylglycerol produced by receptor-mediated hydrolysis of membrane inositol phospholipids as well as by tumor-promoting phorbol ester through the binding of these compounds to the C1 region in its regulatory domain. It is also cleaved by caspase to generate a catalytically active fragment, and it is converted to an active form without proteolysis through the tyrosine phosphorylation reaction. PKC delta activated in distinct ways plays critical roles in cellular functions such as the control of growth, differentiation, and apoptosis.

使用信息

抗体应用

WB, IHC,ELISA,ELISA

稀释比例

WB	IHC
1:1000	1:50

反应性

Human Mouse Rat

MW (kDa)

78kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Kikkawa U, et al. J Biochem. 2002, 132(6):831-9.

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck