PKN2 Rabbit Recombinant mAb Datasheet

生物描述

特异性	PKN2 Rabbit Recombinant mAb detects endogenous level of PKN2.
背景	Protein kinase N (PKN) is a serine/threonine protein kinase with a catalytic domain homologous to protein kinase C and a unique regulatory region containing antiparallel coiled-coil (ACC) domains. PKN is composed of three isoforms (PKN1, PKN2 and PKN3) derived from different genes in mammals. These isoforms are ubiquitously expressed in mammalian tissues, albeit at differing amount. PKN isoforms have been regarded as effectors of Rho family GTPases, and PKN2 (also known as PRK2/PKNγ) is reported to bind to RhoA, RhoB, RhoC and Rac in mammalian tissue. PKN2 contributes to cell-cell contact and cell migration.

特异性

PKN2 Rabbit Recombinant mAb detects endogenous level of PKN2.

背景

Protein kinase N (PKN) is a serine/threonine protein kinase with a catalytic domain homologous to protein kinase C and a unique regulatory region containing antiparallel coiled-coil (ACC) domains. PKN is composed of three isoforms (PKN1, PKN2 and PKN3) derived from different genes in mammals. These isoforms are ubiquitously expressed in mammalian tissues, albeit at differing amount. PKN isoforms have been regarded as effectors of Rho family GTPases, and PKN2 (also known as PRK2/PKNγ) is reported to bind to RhoA, RhoB, RhoC and Rac in mammalian tissue. PKN2 contributes to cell-cell contact and cell migration.

使用信息

抗体应用

WB, IHC,ELISA,ELISA

稀释比例

WB	IHC
1:1000	1:50

反应性

Human Mouse Rat

MW (kDa)

112kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Danno S, et al. Genes Cells. 2017, 22(2):220-236.

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck