PLCG1 Rabbit Recombinant mAb

目录号：A5277

打印

生物描述

特异性 PLCG1 Rabbit Recombinant mAb detects endogenous level of total PLCG1.
背景 Phospholipase C (PLC) is a class of membrane-associated enzymes that cleave phospholipids just before the phosphate group. There are thirteen kinds of mammalian phospholipase C that are classified into six isotypes (β, γ, δ, ε, ζ, η) according to structure. Phospholipase C, gamma 1(PLCG1) catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. It can be activated by receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases. The activated RTKs phosphoylate PLCG1 at tyrosines located at position 472, 771, 775, 783, and 1254. Non-receptor tyrosine kinases interact with PLCG1 in large complexes at the plasma membrane. PLC is a calcium-regulating enzyme and as a modulator of the phosphoinositide balance.

使用信息

抗体应用 WB, IHC,ELISA,ELISA
稀释比例
WB IHC
1:1000 1:50
反应性 Human Mouse Rat
MW (kDa) 149kDa
抗体类型 Rabbit
储存液配方 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件
(自收到货起)		 Store at –20°C.

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck