PPP1R1A Rabbit Recombinant mAb Datasheet

生物描述

特异性	PPP1R1A Rabbit Recombinant mAb detects endogenous level of total PPP1R1A.
背景	Protein phosphatase 1 regulatory subunit 1A (PPP1R1A) is a potent protein phosphatase 1 (PP1) inhibitor, as one of the core targets of EWS/FLI. PPP1R1A is highly expressed at both RNA and protein levels in Ewing sarcoma, but not the putative cell of origin, mesenchymal stem cells, or other sarcomas. Activation and phosphorylation at Thr35 of PPP1R1A by protein kinase A (PKA), is required for PPP1R1A to promote tumorigenesis and metastasis.

特异性

PPP1R1A Rabbit Recombinant mAb detects endogenous level of total PPP1R1A.

背景

Protein phosphatase 1 regulatory subunit 1A (PPP1R1A) is a potent protein phosphatase 1 (PP1) inhibitor, as one of the core targets of EWS/FLI. PPP1R1A is highly expressed at both RNA and protein levels in Ewing sarcoma, but not the putative cell of origin, mesenchymal stem cells, or other sarcomas. Activation and phosphorylation at Thr35 of PPP1R1A by protein kinase A (PKA), is required for PPP1R1A to promote tumorigenesis and metastasis.

使用信息

抗体应用

WB, IHC,ELISA,ELISA

稀释比例

WB	IHC
1:1000	1:50

反应性

Human Mouse Rat

MW (kDa)

27kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Wen Luo, et al. Immunology. 2016, 76(14 Suppl):Abstract nr 544.

Application Data

WB

Validated by Selleck

IHC

Validated by Selleck