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别名 | C-82 prodrug, ICG-001 analog | 储存条件 (自收到货起) |
3年 -20°C 粉状 | |
化学式 | C33H35N6O7P
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分子量 | 658.64 | CAS号 | 1422253-38-0 | |
Solubility (25°C)* | 体外 | DMSO | 100 mg/mL (151.82 mM) | |
Ethanol | 2 mg/mL (3.03 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | PRI-724 (C-82 prodrug, ICG-001 analog) 是一种有效的特异性抑制剂,可破坏 β-catenin 和 CBP 的相互作用。 | ||
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靶点 |
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Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis [ Nat Commun, 2023, 14(1):4671] | PubMed: 37537199 |
Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia [ Cell Rep, 2023, 42(7):112804] | PubMed: 37453060 |
β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer [ J Transl Med, 2023, 21(1):50] | PubMed: 36703130 |
Combinations of PRI-724 Wnt/β-Catenin Pathway Inhibitor with Vismodegib, Erlotinib, or HS-173 Synergistically Inhibit Head and Neck Squamous Cancer Cells [ Int J Mol Sci, 2023, 24(13)10448] | PubMed: 37445628 |
Critical role for ribonucleoside-diphosphate reductase subunit M2 in ALV-J-induced activation of Wnt/β-catenin signaling via interaction with P27 [ J Virol, 2023, 97(8):e0026723] | PubMed: 37582207 |
Machine learning on large scale perturbation screens for SARS-CoV-2 host factors identifies β-catenin/CBP inhibitor PRI-724 as a potent antiviral [ Front Microbiol, 2023, 14:1193320] | PubMed: 37342561 |
PRI-724 and IWP-O1 Wnt Signaling Pathway Inhibitors Modulate the Expression of Glycolytic Enzymes in Tongue Cancer Cell Lines [ Curr Issues Mol Biol, 2023, 45(12):9579-9592] | PubMed: 38132445 |
CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia [ EMBO Mol Med, 2022, e14990] | PubMed: 35253392 |
The Wnt Signaling Pathway Inhibitors Improve the Therapeutic Activity of Glycolysis Modulators against Tongue Cancer Cells [ Int J Mol Sci, 2022, 23-31248] | PubMed: 35163171 |
Periostin Augments Vascular Smooth Muscle Cell Calcification via β-Catenin Signaling [ Biomolecules, 2022, 12(8)1157] | PubMed: 36009051 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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