PRI-724

目录号：S8968 批次号：S896802

打印

化学数据

别名

C-82 prodrug, ICG-001 analog

储存条件
(自收到货起)

3年 -20°C 粉状

化学式

C₃₃H₃₅N₆O₇P

分子量

658.64

CAS号

1422253-38-0

Solubility (25°C)*

体外

DMSO

100 mg/mL (151.82 mM)

Ethanol

10 mg/mL (15.18 mM)

Water

Insoluble

体内（现配现用）

澄清溶液

5%DMSO 1 Corn oil

3.33mg/ml (5.06mM)

以 1 mL 工作液为例，取50μL66.6mg/ml的澄清DMSO储备液加到950μL玉米油中，混合均匀。工作液请现配现用！

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

PRI-724 (C-82 prodrug, ICG-001 analog) 是一种有效的特异性抑制剂，可破坏 β-catenin 和 CBP 的相互作用。

靶点

β-catenin ^[1]

CBP ^[1]

参考文献

PRI-724在文献中得到引用

Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis [ Nat Commun, 2023, 14(1):4671]	PubMed: 37537199
Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia [ Cell Rep, 2023, 42(7):112804]	PubMed: 37453060
β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer [ J Transl Med, 2023, 21(1):50]	PubMed: 36703130
Combinations of PRI-724 Wnt/β-Catenin Pathway Inhibitor with Vismodegib, Erlotinib, or HS-173 Synergistically Inhibit Head and Neck Squamous Cancer Cells [ Int J Mol Sci, 2023, 24(13)10448]	PubMed: 37445628
Critical role for ribonucleoside-diphosphate reductase subunit M2 in ALV-J-induced activation of Wnt/β-catenin signaling via interaction with P27 [ J Virol, 2023, 97(8):e0026723]	PubMed: 37582207
Machine learning on large scale perturbation screens for SARS-CoV-2 host factors identifies β-catenin/CBP inhibitor PRI-724 as a potent antiviral [ Front Microbiol, 2023, 14:1193320]	PubMed: 37342561
PRI-724 and IWP-O1 Wnt Signaling Pathway Inhibitors Modulate the Expression of Glycolytic Enzymes in Tongue Cancer Cell Lines [ Curr Issues Mol Biol, 2023, 45(12):9579-9592]	PubMed: 38132445
CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia [ EMBO Mol Med, 2022, e14990]	PubMed: 35253392
The Wnt Signaling Pathway Inhibitors Improve the Therapeutic Activity of Glycolysis Modulators against Tongue Cancer Cells [ Int J Mol Sci, 2022, 23-31248]	PubMed: 35163171
Periostin Augments Vascular Smooth Muscle Cell Calcification via β-Catenin Signaling [ Biomolecules, 2022, 12(8)1157]	PubMed: 36009051

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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