PRMT5 Rabbit Recombinant mAb Datasheet

生物描述

特异性	PRMT5 Rabbit Recombinant mAb detects endogenous level of total PRMT5.
背景	The protein arginine methyltransferase 5 (PRMT5, also known as Hsl7, Jbp1, Skb1, Capsuleen, or Dart5) is the major enzyme responsible for mono- and symmetric dimethylation of arginine. It is the primary Type II arginine methyltransferase and found in all eukaryotic species. Histone and other protein methylation by PRMT5 regulate genome organization, transcription, stem cells, primordial germ cells, differentiation, the cell cycle, and spliceosome assembly. PRMT5 also directly associates with a range of other protein factors, including pICln, Menin, CoPR5 and RioK1 that may alter its subcellular localization and protein substrate selection. In a variety of somatic cells, PRMT5 predominantly localizes to the cytoplasm and the translocation of PRMT5 appears to play a role in controlling pluripotency in early development of mouse embryos.

特异性

PRMT5 Rabbit Recombinant mAb detects endogenous level of total PRMT5.

背景

The protein arginine methyltransferase 5 (PRMT5, also known as Hsl7, Jbp1, Skb1, Capsuleen, or Dart5) is the major enzyme responsible for mono- and symmetric dimethylation of arginine. It is the primary Type II arginine methyltransferase and found in all eukaryotic species. Histone and other protein methylation by PRMT5 regulate genome organization, transcription, stem cells, primordial germ cells, differentiation, the cell cycle, and spliceosome assembly. PRMT5 also directly associates with a range of other protein factors, including pICln, Menin, CoPR5 and RioK1 that may alter its subcellular localization and protein substrate selection. In a variety of somatic cells, PRMT5 predominantly localizes to the cytoplasm and the translocation of PRMT5 appears to play a role in controlling pluripotency in early development of mouse embryos.

使用信息

抗体应用

WB,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

73kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Stopa N, et al. Cell Mol Life Sci. 2015, 72(11):2041-59.

Application Data

WB

Validated by Selleck