PROX1 Rabbit Recombinant mAb detects endogenous levels of total PROX1.

Prospero-related homeobox 1 (Prox1) is a transcription factor essential for the development of numerous tissues, including the liver. It acts as a negative modulator of the ERRα/PGC-1α axis, and, as such, regulates a broad transcriptional program implicated in the control of energy homeostasis in the liver that includes a newly defined bioenergetic regulon controlled by ERRα. It has also been suggested to play key roles in adult neurogenesis of the hippocampus. In vertebrates, Prox1 is a key regulator for the generation of many organs during embryogenesis such as the brain, spinal cord, retina, lens, liver, pancreas and endothelial lymphatic system.