PDTC (Pyrrolidinedithiocarbamate ammonium)

目录号：S3633 批次号：S363302

化学数据

	别名	APDC, Pyrrolidine dithiocarbamic acid ammonium salt	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₅H₉NS₂.H₃N
	分子量	164.29	CAS号	5108-96-3
Solubility (25°C)*	体外	DMSO	32 mg/mL (194.77 mM)
		Water	32 mg/mL (194.77 mM)
		Ethanol	32 mg/mL (194.77 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述

PDTC (Pyrrolidinedithiocarbamate ammonium)是NF-κB的有效抑制剂，抑制IκB磷酸化、阻止NF-κB易位入核并减少下游细胞因子的表达。

靶点

NF-κB ^[1]

参考文献

[1] Qin JD, et al. Pharm Biol. 2014, 52(11):1460-6.

PDTC (Pyrrolidinedithiocarbamate ammonium)在文献中得到引用

Increased α-HB links colorectal cancer and diabetes by potentiating NF-κB signaling [ Mol Metab, 2023, 75:101766]	PubMed: 37406987
Transgelin promotes lung cancer progression via activation of cancer-associated fibroblasts with enhanced IL-6 release [ Oncogenesis, 2023, 12(1):18]	PubMed: 36990991
Telmisartan inhibits microglia-induced neurotoxic A1 astrocyte conversion via PPARγ-mediated NF-κB/p65 degradation [ Int Immunopharmacol, 2023, 123:110761]	PubMed: 37544025
Photobiomodulation reduces neuropathic pain after spinal cord injury by downregulating CXCL10 expression [ CNS Neurosci Ther, 2023, 10.1111/cns.14325]	PubMed: 37475184
A novel lncRNA DFRV plays a dual function in influenza A virus infection [ Front Microbiol, 2023, 14:1171423]	PubMed: 37303776
Baicalin Relieves LPS-Induced Lung Inflammation via the NF-κB and MAPK Pathways [ Molecules, 2023, 28(4)1873]	PubMed: 36838858
Astragaloside IV Attenuates High-Glucose-Induced Impairment in Diabetic Nephropathy by Increasing Klotho Expression via the NF-κB/NLRP3 Axis [ J Diabetes Res, 2023, 2023:7423661]	PubMed: 37261217
GATA4 Forms a Positive Feedback Loop with CDX2 to Transactivate MUC2 in Bile Acids-Induced Gastric Intestinal Metaplasia [ Gut Liver, 2023, 10.5009/gnl220394]	PubMed: 36860162
Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials [ Int J Oral Sci, 2023, 15(1):31]	PubMed: 37532700
Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma [ Signal Transduct Target Ther, 2022, 7(1):46]	PubMed: 35169126

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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