RAGE Rabbit Recombinant mAb Datasheet

生物描述

特异性	RAGE Rabbit Recombinant mAb detects endogenous level of total RAGE.
背景	The receptor for advanced glycation endproducts (RAGE) is a signal transduction receptor for advanced glycation endproducts (AGEs), the products of nonenzymatic glycation and oxidation of proteins and lipids that accumulate in diabetes and in inflammatory foci. Ligand binding to RAGE in the extracellular space stimulates signal transduction mechanisms that ultimately are responsible for the diverse effects of RAGE on gene expression changes. RAGE is expressed on multiple cell types and that ligand binding stimulates signal transduction cascades such as mitogen-activated protein kinases, phosphatidylinositol 3-kinase, Jak/STAT (signal transducers and activators of transcription), and the Rho GTPases Rac-1 and Cdc42.

特异性

RAGE Rabbit Recombinant mAb detects endogenous level of total RAGE.

背景

The receptor for advanced glycation endproducts (RAGE) is a signal transduction receptor for advanced glycation endproducts (AGEs), the products of nonenzymatic glycation and oxidation of proteins and lipids that accumulate in diabetes and in inflammatory foci. Ligand binding to RAGE in the extracellular space stimulates signal transduction mechanisms that ultimately are responsible for the diverse effects of RAGE on gene expression changes. RAGE is expressed on multiple cell types and that ligand binding stimulates signal transduction cascades such as mitogen-activated protein kinases, phosphatidylinositol 3-kinase, Jak/STAT (signal transducers and activators of transcription), and the Rho GTPases Rac-1 and Cdc42.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

48kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Ravichandran Ramasamy, et al. Ann N Y Acad Sci. 2011, 1243: 88–102.

Application Data

WB

Validated by Selleck