Ret Rabbit Recombinant mAb

生物描述

特异性

Ret Rabbit Recombinant mAb detects endogenous level of total Ret.

背景

The RET proto-oncogene encodes a receptor tyrosine kinase with four cadherin-related motifs and a cysteine-rich region in the extra-cellular domain, and its ligands are glial cell line-derived neurotrophic factor (GDNF) and related molecules, includingneurturin (NRTN), artemin (ARTN) and persephin (PSPN). RET activation by these neurotrophic factors is mediated through aunique multi-component receptor system, consisting of glycosyl-phosphatidylinositol-anchored coreceptor (GFRα1-4) as a ligand-binding component and RET tyrosine kinase as a signaling component. The intracellular domain of RET contains autophosphorylation sites, and phosphorylated tyrosines serve as docking sites for signaling molecules. Like the majority of receptor tyrosine kinases studied, signaling pathways initiated by the RET receptor include the Ras/MAP kinase, PI3 kinase/AKT, and phospholipase C-γ (PLCγ) pathways. In addition to tyrosine autophosphorylation, RET has been found to undergo serine phosphorylation at Ser696 by protein kinase A (PKA).

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	150,175kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Kodama Y, et al. Cancer Sci. 2005, 6(3):143-8. [2] Ibáñez CF. Cold Spring Harb Perspect Biol. 2013, 5(2). pii: a009134. [3] Plaza-Menacho I, et al. Cell Signal. 2014, 26(8):1743-52.

Application Data

WB

IF