RhoA Rabbit Recombinant mAb Datasheet

生物描述

特异性	RhoA Rabbit Recombinant mAb detects endogenous level of total RhoA.
背景	RhoA is a member of the Ras superfamily of small GTP-binding proteins that regulate formation of actin stress fibers and focal adhesions. Like Ras, RhoA cycles between a GDP-bound inactive state and a GTP-bound active state. RhoA-bound nucleotides are regulated by several groups of proteins: guanine nucleotide exchange factors, GTPase-activating proteins, and guanine nucleotide dissociation inhibitors. When GTP-bound, RhoA binds to and activates a number of downstream effectors such as Rho kinase, lipid kinases, and Rhophilin.

特异性

RhoA Rabbit Recombinant mAb detects endogenous level of total RhoA.

背景

RhoA is a member of the Ras superfamily of small GTP-binding proteins that regulate formation of actin stress fibers and focal adhesions. Like Ras, RhoA cycles between a GDP-bound inactive state and a GTP-bound active state. RhoA-bound nucleotides are regulated by several groups of proteins: guanine nucleotide exchange factors, GTPase-activating proteins, and guanine nucleotide dissociation inhibitors. When GTP-bound, RhoA binds to and activates a number of downstream effectors such as Rho kinase, lipid kinases, and Rhophilin.

使用信息

抗体应用

WB ,ELISA,ELISA

稀释比例

WB

1:1000

反应性

Human Mouse Rat

MW (kDa)

22kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Alblas J, et al. Mol Biol Cell. 2001, 12(7):2137-45.

Application Data

WB

Validated by Selleck