RPA70 Rabbit Recombinant mAb

生物描述

特异性

RPA70 Rabbit Recombinant mAb detects endogenous level of total RPA70.

背景

Mammalian RPA is a highly conserved multiunit protein that is also thought to be involved in maintaining genomic stability. RPA is composed of three subunits named for their molecular mass (RPA70, RPA32, and RPA14) and all subunits are necessary for RPA function. RPA co-localises with the MRE11/RAD50/NBS1 (MRN) complex forming repair foci with lesions containing stalled replication forks or single-stranded DNA regions. RPA is likely to participate inDNAreplication and repair processes through its interaction with other proteins and its strong affinity for single-stranded DNA. It interacts specifically with many proteins including p53, XPA, ERCC-1/XPF nuclease, XPG, uracil DNA glycosylase, MRE11, RAD52, and RAD51.

使用信息

抗体应用	WB, IHC, IF,ELISA,ELISA
稀释比例	WB IHC IF 1:1000 1:50 1:50
反应性	Human
MW (kDa)	70kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Sleeth KM, et al. J Mol Biol. 2007, 373(1):38-47.

Application Data

WB

IHC

IF