RRM2 Rabbit Recombinant mAb Datasheet

生物描述

特异性	RRM2 Rabbit Recombinant mAb detects endogenous level of total RRM2.
背景	Ribonucleotide reductase (RR) catalyzes the conversion of ribonucleoside 5′ -diphosphates into their corresponding 2′ -deoxyribonucleoside 5′ -triphosphates that are necessary for DNA replication and repair. Human RR comprises two subunits, RRM1 and RRM2. The cellular RRM1 protein level is relatively stable through the entire cell cycle, whereas RRM2 is only expressed during the late G1/early S phase when DNA replication occurs. RRM2 subunit is the primary regulator of RR enzymatic activity. RRM2 is known to be involved in chemoresistance.

特异性

RRM2 Rabbit Recombinant mAb detects endogenous level of total RRM2.

背景

Ribonucleotide reductase (RR) catalyzes the conversion of ribonucleoside 5′ -diphosphates into their corresponding 2′ -deoxyribonucleoside 5′ -triphosphates that are necessary for DNA replication and repair. Human RR comprises two subunits, RRM1 and RRM2. The cellular RRM1 protein level is relatively stable through the entire cell cycle, whereas RRM2 is only expressed during the late G1/early S phase when DNA replication occurs. RRM2 subunit is the primary regulator of RR enzymatic activity. RRM2 is known to be involved in chemoresistance.

使用信息

抗体应用

WB, IF,ELISA,ELISA

稀释比例

WB	IF
1:1000	1:50

反应性

Human

MW (kDa)

45kDa

抗体类型

Rabbit

储存液配方

10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.

储存条件
(自收到货起)

Store at –20°C.

文献参考

[1] Rahman MA, et al. Clin Cancer Res. 2013, 19(13):3416-28.

Application Data

WB

Validated by Selleck

IF

Validated by Selleck