S100A4 Rabbit Recombinant mAb

生物描述

特异性

S100A4 Rabbit Recombinant mAb detects endogenous level of total S100A4.

背景

The S100 family of calcium binding proteins has been shown to be involved in a variety of physiological function, such as cell proliferation, extracellular signal transduction, intercellular adhesion, motility as well as cancer metastasis. The protein encoded by S100A4 gene is now known to be capable of regulating cell cycle progression, modulating intercellular adhesion and invasive and metastatic properties of cancer cells. S100A4 is expressed in several adult mouse and rat tissues, with high expression found in the spleen, thymus, bone marrow, T-lymphocytes, neutrophils, and macrophages. Intracellularly, S100A4 binds to several targets regulating cytoskeletal dynamics and cell motility and proliferation. It is secreted from both tumour and non-malignant cells, and exerts extracellular effects regulating, in particular, angiogenesis, cell migration and cardiomyocyte differentiation and hypertrophy.

使用信息

抗体应用	WB, IHC, IF,ELISA,ELISA
稀释比例	WB IHC IF 1:1000 1:50 1:50
反应性	Human Mouse Rat
MW (kDa)	12kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Sherbet GV, et al. Anticancer Res. 1998, 18(4A):2415-21. [2] Garrett SC, et al. J Biol Chem. 2006, 281(2):677-80. [3] Dmytriyeva O, et al. Nat Commun. 2012, 3:1197.

Application Data

WB

IHC

IF