生物描述

特异性

SATB2 Rabbit Recombinant mAb detects endogenous levels of total SATB2.

背景

SATB2 is a member of the family of special AT-rich binding proteins that binds to MARs and activates transcription in a MAR-dependent manner. It is closely related to the thymocyte-specific SATB1 protein. SATB1 act as a repressor of transcription by recruiting the Sin3a histone deacetylase and subunits of the ACF nucleosome-mobilizing complex to target genes. SSATB2 is abundantly expressed in a subset of postmitotic differentiating neurons in the neocortex that is involved in regulating gene expression through altering chromatin structure in differentiating cortical neurons. In the developing brain, the pattern of expression of SATB1 and SATB2 is not overlapping suggesting that they regulate the differentiation of distinct populations of neurons. Accordingly, SATB1 and SATB2 can be used as markers to identify distinct subsets of differentiating cortical neurons. SATB2 is a marker of osteoblastic differentiation in benign and malignant mesenchymal tumours. Although SATB2 is not specific for osteosarcoma, it has the potential to be a useful adjunct in some specific settings, when either: (i) the appearances of the extracellular matrix are equivocal or (ii) the biopsy only samples tumour with an undifferentiated appearance.

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	81kDa
抗体类型
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Dobreva G, et al. Cell. 2006, 125(5):971-86. [2] Szemes M, et al. Neurochem Res. 2006, 31(2):237-46. [3] Conner JR, et al. Histopathology. 2013, 63(1):36-49.

Application Data

WB

IF