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别名 | N/A | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
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化学式 | C20H21FN4O2 |
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分子量 | 368.4 | CAS号 | 193551-21-2 | ||||
Solubility (25°C)* | 体外 | DMSO | 60 mg/mL (162.86 mM) | ||||
Ethanol | 7 mg/mL (19.0 mM) | ||||||
Water | Insoluble | ||||||
体内(现配现用) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | SB239063是一种有效的选择性p38 MAPKα/β抑制剂,IC50为44 nM,对γ- 和 δ-激酶亚型没有活性。 | ||||
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靶点 |
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, Oncogene, 2017, 36(23):3312-3321
Inhibition of Macropinocytosis Enhances the Sensitivity of Osteosarcoma Cells to Benzethonium Chloride [ Cancers (Basel), 2023, 15(3)961] | PubMed: 36765917 |
Microglial P2Y12 Signaling Contributes to Cisplatin-induced Pain Hypersensitivity via IL-18-mediated Central Sensitization in the Spinal Cord [ J Pain, 2023, S1526-5900(23)00013-5] | PubMed: 36646400 |
Conjugated secondary 12α-hydroxylated bile acids promote liver fibrogenesis [ EBioMedicine, 2021, 66:103290] | PubMed: 33752128 |
Cardamonin inhibits the growth of human osteosarcoma cells through activating P38 and JNK signaling pathway [ Biomed Pharmacother, 2021, 134:111155] | PubMed: 33370628 |
Polysaccharides from Ulva prolifera O.F. Müller inhibit cell proliferation via activating MAPK signaling in A549 and H1650 cells [ Food Funct, 2021, 12(15):6915-6924] | PubMed: 34132294 |
Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-κB/MLCK and Nrf2 Signaling Pathways [ J Agric Food Chem, 2021, 10.1021/acs.jafc.1c00199] | PubMed: 33749262 |
A phospho-regulated ensemble signal motif of α-TAT1 drives dynamic microtubule 1 acetylation 2 [ HAL open science, 2021, 10.1101/2020.09.23.310235] | PubMed: None |
A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38. [ Redox Biol, 2020, 28:101445] | PubMed: 32037305 |
Chronic-plus-binge Alcohol Intake Induces Production of Proinflammatory mtDNA-enriched Extracellular Vesicles and Steatohepatitis via ASK1-p38MAPKα-dependent Mechanisms [ JCI Insight, 2020, 136496] | PubMed: 32544093 |
p38α Regulates Expression of DUX4 in a Model of Facioscapulohumeral Muscular Dystrophy [ J Pharmacol Exp Ther, 2020, 374(3):489-498] | PubMed: 32576599 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
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