全国免费电话:400-668-6834 -- 仅限中国地区 -- |
在线订购:QQ: 4006686834 电话订购:021-68591985 邮件订购:info@selleck.cn 我们也提供销售人员上门服务 |
技术支持电话:400-168-6834 我们将于一个工作日与您联系 |
别名 | N/A | 储存条件 (自收到货起) |
3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂 |
|
化学式 | C29H23N7O2S2 |
|||
分子量 | 565.67 | CAS号 | 913822-46-5 | |
Solubility (25°C)* | 体外 | DMSO | 41 mg/mL (72.48 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
产品描述 | SC75741 是强效的NF-κB抑制剂,其EC50为200 nM。SC75741 可有效地阻断流感病毒的传播。 | ||
---|---|---|---|
靶点 |
|
||
体外研究 | SC75741通过抑制人PBMC增殖显示出免疫抑制活性,IC50为2.2 μM。[1] SC75741通过在转录水平抑制NF-κB介导的信号通路抑制A型和B 型流感病毒。此外,SC75741对抗病毒变异体的发展显示出高阻隔作用。[2] | ||
体内研究 | 注射H5N1病毒后,SC75741 (15 毫克/千克,腹腔注射)减少小鼠肺中病毒复制和细胞因子的表达。[2] | ||
特征 | NF-κB选择性抑制剂。 |
激酶实验 | NF-κB报告基因分析 | |
---|---|---|
NF-κB报告基因分析根据制造商的说明用A549-NF-κB-SEAP细胞系进行。简而言之,接种稳定转染pNF-κB-SEAP 报告基因质粒的A549细胞,并允许其附着过夜。随后细胞与浓度为100,30,10,3,1,0.3,0.1,和0 μM的描述的化合物培养5小时,然后用10纳克/毫升TNF-α刺激22小时。SEAP活性使用化学发光的SEAP报告基因测定法通过分析细胞的上层清夜进行检测。 | ||
细胞实验 | 细胞系 | 人 PBMCs |
浓度 | ~50 μM | |
处理时间 | 48小时 | |
方法 | 细胞活性测定使用CellTiter-BluTM细胞活性检测法进行。每种浓度的化合物重复测量四次。 | |
动物实验 | 动物模型 | 注射 H5N1流感病毒的C57BL/6 小鼠 |
剂量 | ~15 毫克/千克 | |
给药处理 | 腹腔注射 |
|
数据来源于[Data independently produced by , , Oncotarget, 2016, 7(32):52281-52293]
数据来源于[Data independently produced by , , J Nutr Biochem, 2017, 41:56-64]
数据来源于[Data independently produced by , , J Nutr Biochem, 2016, 41:56-64. ]
数据来源于[Data independently produced by , , Biomed Pharmacother, 2019, 109:1978-1987]
Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth [ J Exp Clin Cancer Res, 2023, 42(1):25] | PubMed: 36670508 |
A Disintegrin and Metalloproteinase with Thrombospondin Motifs 4 Regulates Pulmonary Vascular Hyperpermeability through Destruction of Glycocalyx in Acute Respiratory Distress Syndrome [ Int J Mol Sci, 2023, 10.3390/ijms242216230] | PubMed: 38003418 |
Development of a nanoparticle-based immunotherapy targeting PD-L1 and PLK1 for lung cancer treatment [ Nat Commun, 2022, 13(1):4261] | PubMed: 35871223 |
Development of a nanoparticle-based immunotherapy targeting PD-L1 and PLK1 for lung cancer treatment [ Nat Commun, 2022, 13(1):4261] | PubMed: 35871223 |
Oocytes could rearrange immunoglobulin production to survive over adverse environmental stimuli [ Front Immunol, 2022, 13:990077] | PubMed: 36405746 |
Oocytes could rearrange immunoglobulin production to survive over adverse environmental stimuli [ Front Immunol, 2022, 13:990077] | PubMed: 36405746 |
Homogeneous Polyporus Polysaccharide Inhibit Bladder Cancer by Resetting Tumor-Associated Macrophages Toward M1 Through NF-κB/NLRP3 Signaling [ Front Immunol, 2022, 13:839460] | PubMed: 35603205 |
IFNγ directly counteracts imatinib-induced apoptosis of primary human CD34+ CML stem/progenitor cells potentially through the upregulation of multiple key survival factors [ Oncoimmunology, 2022, 11(1):2109861] | PubMed: 35979386 |
Tumor-Derived C-C Motif Ligand 2 Induces the Recruitment and Polarization of Tumor-Associated Macrophages and Increases the Metastatic Potential of Bladder Cancer Cells in the Postirradiated Microenvironment [ Int J Radiat Oncol Biol Phys, 2022, S0360-3016(22)00598-3] | PubMed: 35691449 |
Withaphysalins from Medicinal and Edible Physalis minima and Their Anti-inflammatory Activities [ J Agric Food Chem, 2022, 70(18):5595-5609] | PubMed: 35476903 |
特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品,在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同,大多数建议储存在-20°C,抑制剂属于化学试剂,可在常温下运输储存两周左右。即使如此,我们保证产品的出货量将保持产品质量的条件下,一般都会放入冰袋。望阁下收到产品后,请按照产品数据表建议适当存储。
如果需要长期保存,请于零下二十度低温保存。禁止用于人体及治疗!
退换货政策
Selleck提供宽松的退换货承诺,努力为您营造最优的购物体验。每个订单Selleck只提供一次退换货服务,为了确保您的权益,请您仔细阅读以下内容:
1. 请在返还样品之前事先与我们取得联系,以确保产品是直接向我们或者当地代理商购买的;
2. 自收到货物起七天内,如因运输过程有问题或其他任何问题,您可以提出退换货要求;自收到货物起365天内,如因产品质量有问题,您可以提出退换货要求。
3. 请使用我们的快递账号进行退换货,您无需为此承担任何费用。
4. 如您已收到由Selleck开具的发票,则办理退货或订单金额发生变更的换货时,请将发票随商品一同返还给Selleck。请您妥善保管发票,如发票丢失,将无法办理退换货手续。
5. 对于合理的退换货要求,我们会在5个工作日内处理完成您的款项退还和新换货物的运输等,请耐心等待。