SHP1 Rabbit Recombinant mAb

生物描述

特异性

SHP1 Rabbit Recombinant mAb detects endogenous level of total SHP1.

背景

SHP-1 or PTPN6 (previously also referred to as SH-PTP1, PTP1C, HCP, or Hcph) is expressed predominantly in hematopoietic cells of all lineages and all stages of maturation and functions as an important regulator of multiple signaling pathways in hematopoietic cells, while it is expressed at low levels in epithelial cells. In contrast, the structurally close relative SHP-2 or PTPN11 (previously called SH-PTP2, PTP1D, PTP2c, SHPTP-3, or SYP) is ubiquitously expressed including in cells that express SHP-1. Both SHP-1 and SHP-2 are critical regulators of T-cell development, function, and differentiation. SHP1 is thought to be a negative regulator of growth and functions to terminate signals.

使用信息

抗体应用	WB, IHC,ELISA,ELISA
稀释比例	WB IHC 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	68kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Ulrike Lorenz. Immunol Rev. 2009, 228(1): 342–359. [2] Abram CL, et al. J Leukoc Biol. 2017, 102(3):657-675. [3] Heather Bone, et al. JBC. 1997, 272: 14470-14476.

Application Data

WB

IHC