Silmitasertib (CX-4945) sodium salt

目录号：S0707 批次号：S070704

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 -20°C 粉状
	化学式	C₁₉H₁₁ClN₃NaO₂
	分子量	371.75	CAS号	1309357-15-0
Solubility (25°C)*	体外	DMSO	37 mg/mL (99.52 mM)
		Water	5 mg/mL (13.44 mM)
		Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

生物活性

产品描述

Silmitasertib (CX-4945) sodium salt是一种有效的、口服可生物利用的、选择性的 casein kinase 2 (CK2) 的抑制剂，对CK2α和CK2α'的IC50值为1 nM。

靶点

CK2α ^[1] (Cell-free assay)	CK2α' ^[1] (Cell-free assay)
1 nM	1 nM

参考文献

[1] Adam Siddiqui-Jain, et al. Cancer Res. 2010 Dec 15;70(24):10288-98.

Silmitasertib (CX-4945) sodium salt在文献中得到引用

CK2 activity is crucial for proper glucagon expression [ Diabetologia, 2024, 10.1007/s00125-024-06128-1]	PubMed: 38503901
AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity [ Proc Natl Acad Sci U S A, 2022, 119(12):e2114336119]	PubMed: 35290121
Inhibition of casein kinase 2 sensitizes mantle cell lymphoma to venetoclax through MCL-1 downregulation [ Haematologica, 2022, 10.3324/haematol.2022.281668]	PubMed: 36226498
CK2 blockade alleviates liver fibrosis by suppressing activation of hepatic stellate cells via the Hedgehog pathway [ Br J Pharmacol, 2022, 10.1111/bph.15945]	PubMed: 36070072
Protein Kinase CK2 acts as a molecular brake to control NADPH oxidase 1 activation and colon inflammation [ Cell Mol Gastroenterol Hepatol, 2022, S2352-345X(22)00003-0]	PubMed: 35031518
Anti-adipogenic and Pro-lipolytic Effects on 3T3-L1 Preadipocytes by CX-4945, an Inhibitor of Casein Kinase 2 [ Int J Mol Sci, 2022, 23(13)7274]	PubMed: 35806278
Inhibitory Response to CK II Inhibitor Silmitasertib and CDKs Inhibitor Dinaciclib Is Related to Genetic Differences in Pancreatic Ductal Adenocarcinoma Cell Lines [ Int J Mol Sci, 2022, 23(8)4409]	PubMed: 35457227
Targeting AKT and CK2 represents a novel therapeutic strategy for SMO constitutive activation-driven medulloblastoma [ CNS Neurosci Ther, 2022, 10.1111/cns.13835]	PubMed: 35419951
CIGB-300 Peptide Targets the CK2 Phospho-Acceptor Domain on Human Papillomavirus E7 and Disrupts the Retinoblastoma (RB) Complex in Cervical Cancer Cells [ Viruses, 2022, 14(8)1681]	PubMed: 36016303
Targeting of Protein Kinase CK2 Elicits Antiviral Activity on Bovine Coronavirus Infection [ Viruses, 2022, 14(3)552]	PubMed: 35336959

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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