SIRT6 Rabbit Recombinant mAb

SIRT6 Antibody detects endogenous levels of SIRT6.

Sirtuins are the mammalian homologs of the yeast histone deacetylase Sir2. Among members of this family, SIRT6 appears to have particular significance in regulating metabolism, DNA repair and lifespan. It is a major player in energy homeostasis. SIRT6 associates specifically with telomeres, and SIRT6 depletion leads to telomere dysfunction with end-to-end chromosomal fusions and premature cellular senescence. A recent research reports that SIRT6 regulates HSC homeostasis through the transcriptional repression of Wnt target genes. Mechanistically, SIRT6 inhibits the transcription of Wnt target genes by interacting with transcription factor LEF1 and deacetylating histone 3 at lysine 56. Pharmacological inhibition of the Wnt pathway rescues the aberrant proliferation and functional defect in SIRT6-deficient HSCs.