Stathmin 1 Rabbit Recombinant mAb

生物描述

特异性

Stathmin 1 Rabbit Recombinant mAb detects endogenous level of total Stathmin 1.

背景

As a microtubule destabilizing protein, STMN1 regulates cytoskeletal dynamics, cell cycle progression, mitosis, and cell migration. STMN1 is a ubiquitous cytoplasmic phosphoprotein that regulates microtubule dynamics. STMN1 depolymerizes microtubules and is required for all cellular processes involving microtubule rearrangement, most notably mitosis. At the onset of mitosis, STMN1 rapidly destabilizes interphase microtubules, allowing them to be reorganized into a mitotic spindle. During spindle assembly, STMN1 activity is repressed through phosphorylation, thus enabling repolymerization. Following chromosomal segregation, STMN1 is once again activated in order to disassemble the spindle and begin cytoskeleton reconstruction. STMN1 activity is therefore critically important for both successful M-phase entry and timely M-phase exit. Independent from its role in cell division, STMN1 has also been shown to regulate cell motility, enhance cell migration, and promote metastasis.

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human Mouse Rat
MW (kDa)	18kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Karst AM, et al. Gynecol Oncol. 2011, 123(1):5-12.

Application Data

WB

IF