Tauroursodeoxycholic Acid (TUDCA)

目录号：S3654 批次号：S365404

化学数据

	别名	N/A	储存条件 (自收到货起)	3年 / -20°C / 粉状 1年 / -80°C / 溶于溶剂
	化学式	C₂₆H₄₅NO₆S
	分子量	499.70	CAS号	14605-22-2
Solubility (25°C)*	体外	DMSO	100 mg/mL (200.12 mM)
		Ethanol	70 mg/mL (140.08 mM)
		Water	10 mg/mL (20.01 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述	Tauroursodeoxycholic acid (TUDCA)是乌索脱氧胆酸的牛磺酸共轭产物，在多种神经退行性疾病，如阿尔茨海默病、帕金森疾病和亨廷顿疾病中，可作为线粒体稳定剂和抗凋亡试剂。

参考文献

Tauroursodeoxycholic Acid (TUDCA)在文献中得到引用

Advanced oxidation protein products induce Paneth cells defects by endoplasmic reticulum stress in Crohn's disease [ iScience, 2023, 26(8):107312]	PubMed: 37539032
Routes of Albumin Overload Toxicity in Renal Tubular Epithelial Cells [ Int J Mol Sci, 2023, 24(11)9640]	PubMed: 37298591
Tauroursodeoxycholic Acid Supplementation in In Vitro Culture of Indicine Bovine Embryos: Molecular and Cellular Effects on the In Vitro Cryotolerance [ Int J Mol Sci, 2023, 24(18)14060]	PubMed: 37762363
Tauroursodeoxycholic acid protects Schwann cells from high glucose-induced cytotoxicity by targeting NLRP3 to regulate cell migration and pyroptosis [ Biotechnol Appl Biochem, 2023, 10.1002/bab.2518]	PubMed: 37749820
Very-low-density lipoprotein receptor-enhanced lipid metabolism in pancreatic stellate cells promotes pancreatic fibrosis [ Immunity, 2022, 55(7):1185-1199.e8]	PubMed: 35738281
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance [ Nat Cell Biol, 2022, 24(2):168-180]	PubMed: 35165418
Tauroursodeoxycholic acid functions as a critical effector mediating insulin sensitization of metformin in obese mice [ Redox Biol, 2022, 57:102481]	PubMed: 36148770
Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85α [ Cell Death Dis, 2022, 13(7):643]	PubMed: 35871160
Endoplasmic reticulum stress contributes to cisplatin-induced chronic kidney disease via the PERK-PKCδ pathway [ Cell Mol Life Sci, 2022, 79(8):452]	PubMed: 35895146
S1PR2/RhoA/ROCK1 pathway promotes inflammatory bowel disease by inducing intestinal vascular endothelial barrier damage and M1 macrophage polarization [ Biochem Pharmacol, 2022, 201:115077]	PubMed: 35537530

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如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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