TDP43 Rabbit Recombinant mAb

生物描述

特异性

TDP43 Rabbit Recombinant mAb detects endogenous level of total TDP43.

背景

TDP-43 is a transcriptional repressor that binds to chromosomally integrated TAR DNA (an mRNA binding protein) and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. In particular, TDP-43 is a splicing factor binding to the intron8/exon9 junction of the CFTR gene and to the intron2/exon3 region of the apoA-II gene. TDP-43 is the principle protein component of inclusions in ALS and ubiquitin positive frontotemporal lobar degeneration (FTLD-U). Although it is ubiquitously expressed in all tissues, it highly expresses in the brain and kidney. TDP-43 predominantly expresses in the nucleus where it exerts its biological functions, but in pathological tissue TDP-43 is aberrantly processed and forms inclusions in the cytoplasm.

使用信息

抗体应用	WB, IF,ELISA,ELISA
稀释比例	WB IF 1:1000 1:50
反应性	Human Mouse Rat Zebrafish
MW (kDa)	45kDa
抗体类型	Rabbit
储存液配方	10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide.
储存条件 (自收到货起)	Store at –20°C.

文献参考

[1] Ou SH, et al. J Virol. 1995, 69(6):3584-96. [2] Liu-Yesucevitz L, et al. PLoS One. 2010, 5(10):e13250.

Application Data

WB

IF