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目录号:A2012 批次号: A201204
Tocilizumab (anti-human IL-6R)是人源单克隆单体,可与interleukin-6 receptor结合发挥抑制作用。MW: 148 KD。
CAS号 | 375823-41-9 |
---|---|
配制 | PBS buffer, pH 7.2 |
推荐同型对照 | Human IgG1 |
来源 | CHO cells |
储存条件 (自收到货起) |
Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles |
纯度 | 99% |
蛋白浓度 | 7.5mg/ml |
内毒素 | <1EU/mg |
Autoimmunity in Down's syndrome via cytokines, CD4 T cells and CD11c+ B cells [ Nature, 2023, 615(7951):305-314] | PubMed: 36813963 |
Peripheral helper-T-cell-derived CXCL13 is a crucial pathogenic factor in idiopathic multicentric Castleman disease [ Nat Commun, 2023, 14(1):6959] | PubMed: 37907518 |
Anti-inflammatory effect of interleukin-6 highly enriched in secretome of two clinically relevant sources of mesenchymal stromal cells [ Front Cell Dev Biol, 2023, 11:1244120] | PubMed: 37745306 |
Cancer-associated fibroblasts induce growth and radioresistance of breast cancer cells through paracrine IL-6 [ Cell Death Discov, 2023, 9(1):6] | PubMed: 36635302 |
The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury [ Int J Mol Sci, 2023, 24(11)9692] | PubMed: 37298645 |
ENO1 Promotes OSCC Migration and Invasion by Orchestrating IL-6 Secretion from Macrophages via a Positive Feedback Loop [ Int J Mol Sci, 2023, 24(1)737] | PubMed: 36614179 |
Anti-inflammatory effect of interleukin-6 highly enriched in secretome of two clinically relevant sources of mesenchymal stromal cells [ Front Cell Dev Biol, 2023, 11:1244120] | PubMed: 37745306 |
IL-6 Plays a Critical Role in Stromal Fibroblast RANKL Induction and Consequent Osteoclastogenesis in Ameloblastoma Progression [ Lab Invest, 2023, 103(1):100023] | PubMed: 36748192 |
Characterization of HZ0412a, a novel potent humanized anti-IL-6 receptor antibody that blocks IL-6R binding to gp130 [ Antib Ther, 2023, 6(2):119-126] | PubMed: 37324549 |
Overexpression of microRNA-145 enhanced docetaxel sensitivity in breast cancer cells via inactivation of protein kinase B gamma-mediated phosphoinositide 3-kinase -protein kinase B pathway [ Signal Transduct Target Ther, 2022, 7(1):52] | PubMed: 35194016 |
禁止用于人体及治疗!