Tocilizumab (anti-IL-6R)

目录号：A2012         批次号: A201205

打印

Tocilizumab (anti-human IL-6R)是人源单克隆单体，可与interleukin-6 receptor结合发挥抑制作用。MW: 148 KD。

抗体信息

CAS号 ‎375823-41-9
配制 PBS buffer, pH 7.2
推荐同型对照 Human IgG1
来源 CHO cells
储存条件
(自收到货起)		 Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles
纯度 99%
蛋白浓度 14.29mg/ml
内毒素 ＜1EU/mg

Tocilizumab (anti-IL-6R)在文献中得到引用

Autoimmunity in Down's syndrome via cytokines, CD4 T cells and CD11c+ B cells [ Nature, 2023, 615(7951):305-314] PubMed: 36813963
Peripheral helper-T-cell-derived CXCL13 is a crucial pathogenic factor in idiopathic multicentric Castleman disease [ Nat Commun, 2023, 14(1):6959] PubMed: 37907518
Anti-inflammatory effect of interleukin-6 highly enriched in secretome of two clinically relevant sources of mesenchymal stromal cells [ Front Cell Dev Biol, 2023, 11:1244120] PubMed: 37745306
Cancer-associated fibroblasts induce growth and radioresistance of breast cancer cells through paracrine IL-6 [ Cell Death Discov, 2023, 9(1):6] PubMed: 36635302
The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury [ Int J Mol Sci, 2023, 24(11)9692] PubMed: 37298645
ENO1 Promotes OSCC Migration and Invasion by Orchestrating IL-6 Secretion from Macrophages via a Positive Feedback Loop [ Int J Mol Sci, 2023, 24(1)737] PubMed: 36614179
Anti-inflammatory effect of interleukin-6 highly enriched in secretome of two clinically relevant sources of mesenchymal stromal cells [ Front Cell Dev Biol, 2023, 11:1244120] PubMed: 37745306
IL-6 Plays a Critical Role in Stromal Fibroblast RANKL Induction and Consequent Osteoclastogenesis in Ameloblastoma Progression [ Lab Invest, 2023, 103(1):100023] PubMed: 36748192
Characterization of HZ0412a, a novel potent humanized anti-IL-6 receptor antibody that blocks IL-6R binding to gp130 [ Antib Ther, 2023, 6(2):119-126] PubMed: 37324549
Overexpression of microRNA-145 enhanced docetaxel sensitivity in breast cancer cells via inactivation of protein kinase B gamma-mediated phosphoinositide 3-kinase -protein kinase B pathway [ Signal Transduct Target Ther, 2022, 7(1):52] PubMed: 35194016

禁止用于人体及治疗！