Topotecan

目录号：S9321 批次号：S932104

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化学数据

化学结构式 别名 NSC609699,Nogitecan,SKFS 104864A 储存条件
(自收到货起)		 3年 -20°C 粉状
化学式

C23H23N3O5
分子量 421.45 CAS号 123948-87-8
Solubility (25°C)* 体外 DMSO 84 mg/mL (199.31 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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生物活性

产品描述 Topotecan(NSC609699,Nogitecan,SKFS 104864A) 是一种用于治疗卵巢癌的抗肿瘤药物，通过抑制DNA拓扑异构酶起作用。
靶点
Topo I [1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

Topotecan在文献中得到引用

Identification and targeting of protein tyrosine kinase 7 (PTK7) as an immunotherapy candidate for neuroblastoma [ Cell Rep Med, 2023, 4(6):101091] PubMed: 37343516
Immune suppressive signaling regulated by latent transforming growth factor beta binding protein 1 promotes metastasis in cervical cancer [ Braz J Med Biol Res, 2023, 55:e12206] PubMed: 36629522
FL118, acting as a 'molecular glue degrader', binds to dephosphorylates and degrades the oncoprotein DDX5 (p68) to control c-Myc, survivin and mutant Kras against colorectal and pancreatic cancer with high efficacy [ Clin Transl Med, 2022, 12(5):e881] PubMed: 35604033
Secreted HSP90α-LRP1 Signaling Promotes Tumor Metastasis and Chemoresistance in Pancreatic Cancer [ Int J Mol Sci, 2022, 23(10)5532] PubMed: 35628341
Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan [ Molecules, 2022, 27(11)3374] PubMed: 35684313
Immunogenicity of small-cell lung cancer associates with STING pathway activation and is enhanced by ATR and TOP1 inhibition [ Cancer Med, 2022, 10.1002/cam4.5109] PubMed: 35957613
SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria [ Nat Commun, 2021, 12(1):5404] PubMed: 34518526
Camptothecin and topotecan, inhibitors of transcription factor Fli-1 and topoisomerase, markedly ameliorate lupus nephritis in NZBWF1 mice and reduce the production of inflammatory mediators in human renal cells [ Arthritis Rheumatol, 2021, 10.1002/art.41685] PubMed: 33559345
Chemoresistance is mediated by ovarian cancer leader cells in vitro [ J Exp Clin Cancer Res, 2021, 40(1):276] PubMed: 34470672
FK228 potentiates topotecan activity against small cell lung cancer cells via induction of SLFN11 [ Acta Pharmacol Sin, 2021, 10.1038/s41401-021-00817-y] PubMed: 34893686

特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20°C，抑制剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。

如果需要长期保存，请于零下二十度低温保存。禁止用于人体及治疗！

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